Variations in Antioxidant Genes and Male Infertility

P-201: The Role of P53 Family Members in Infertility

Background: P53, p63, and p73 transcription factors which are belong to The p53 family, are conserved during evolution. They have important roles in many molecular and cellular functions, including tumor suppression, the development of epithelial cell layers, and the development of central nervous system and immune system. Studies show these molecules also have role in maintaining the genomic i...

I-38: Search for Genetic Causes of Male Infertility

Background: We are convinced that better infertility treatment will only be achieved with a better under understanding of the molecular mechanisms specific to each patient. To that effect we want to indentify genes involved in male infertility. Materials and Methods: We screened cohorts of infertile men to identify the cause of their infertility. Results: Our team has identified and caracterize...

I-5: Alteration in ?-Defensin 126 Genes Associated with Unexplained Male Infertility and ART Outcomes

O-8: Some Variations of the TSSK2 Gene May be Associated with Impaired Spermatogenesis

Background: Tssk2, a member of the testis specific serine/threonine kinase (TSSK) family, is expressed predominantly in the testis and crucial for the formation and function of the sperm cells in mouse. Targeted deletion of Tssk1 and 2 in male chimeric mice caused infertility due to haploinsufficiency of the genes. Therefore it is reasonable to postulate that mutations in its human homologue TS...

P-209: Decreased Expression of Histone Acetyltransferase CDY1 Gene in Testis Tissue May Lead to Decreased Expression of Transition Protein (TNP) and Protamine (PRM) Genes,Causing Male Infertility

Background: Infertility is a complex medical problem. About 15% of couples are infertile, and male infertility being involved in roughly 50% of the cases. Among these, many cases are associated with a severe impairment of spermatogenesis. During the last stage of spermatogenesis (spermiogenesis), sperm chromatin endures complex modifications in which histones are lost and depositioned with tran...